Hi Orko,
Make sure that you have disabled your on-board sound card. If it’s not disabled, then the computer will just default back to it from time to time, especially in windows media or itunes.
Other than that, make sure that you have the 2.46 drivers and if it’s still not working, do an uninstall and reinstall.
If you're still having problems after all this, contact me at
kbenton@presonus.com and we'll get you going.
Katelyn Benton
PreSonus Audio Electronics
Kbenton@presonus.com